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A very beautifully written episode by Glen Morgan (James Wong is only credited as director, but I bet he had some part in writing the script too), but not part of the canon mytharc

The experimental film's fortunes rise and fall around the dryly comic talents of Aubrey Plaza, who delivers in a major way, exploring the playful cruelty she's subtly hinted at in many of her comedic roles

sustained nicotine exposure leads to upregulation of the receptors in the prefrontal cortex, pathways which are involved in cognitive control, and which are not fully matured until the mid-twenties

Opportunistic infections and neurological complications can impair breathing